Harrat Uwayrid Nature Reserve, or Harrat Uwayrid Biosphere Reserve, is a nature reserve located in the Al-Ula Governorate in the Al Madinah Region in the north of the Kingdom of Saudi Arabia. Harrat Uwayrid is a volcanic area with rugged terrain, with many valleys and volcanic craters.
The nature reserve in Harrat Uwayrid includes many species of rare plants, in addition to endemic and prey birds and about 19 species of endangered animals.

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Harrat Uwayrid Nature Reserve is included in the UNESCO World Network of Biosphere Reserves (WNBR).
Designation date: 2022